• Discovery and validation of mucosal TNF expression combined with histological score-a biomarker for personalized treatment in ulcerative colitis 

      Florholmen, Jon; Johnsen, Kay-Martin; Meyer, Renate; Olsen, Trine; Moe, Øystein Kittel; Tandberg, Petter; Gundersen, Mona Dixon; Kvamme, Jan-Magnus; Johnsen, Knut; Løitegård, Terje; Raschpichler, Gabriele; Vold, Cecilia; Sørbye, Sveinung; Goll, Rasmus (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-02)
      <i>Background</i> - There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of clinical outcome in the first year following diagnosis.<p> <p><i>Methods</i> - Treatment naive-patients with ulcerative colitis were included at time of initial diagnosis ...
    • Evaluation of absolute quantitation by nonlinear regression in probe-based real-time PCR 

      Olsen, Trine; Goll, Rasmus; Florholmen, Jon; Cui, Guanglin (Journal article; Tidsskriftartikkel; Peer reviewed, 2006-03-03)
      Background In real-time PCR data analysis, the cycle threshold (CT) method is currently the gold standard. This method is based on an assumption of equal PCR efficiency in all reactions, and precision may suffer if this condition is not met. Nonlinear regression analysis (NLR) or curve fitting has therefore been suggested as an alternative to the cycle threshold method for absolute quantitation. ...
    • Kommunale barnevernets kompetanse i samtale med barn. Hvilken sammenheng er det mellom kommunale barnevernansattes kompetansenivå og trygghet i egen kompetanse i samtale med barn? 

      Olsen, Trine (Master thesis; Mastergradsoppgave, 2022-05-13)
      Barneverntjenesten er et komplisert arbeidsfelt som krever bred kunnskap og forståelse om barn,- unge og deres familier. Det gjøres vanskelige vurderinger og beslutninger som påvirker livet til barn og foreldre eller andre omsorgspersoner. Et av barneverntjenestens ansvar er å utrede omsorgssituasjonen til barn og iverksette passende tiltak som sikrer barnet en trygg og forutsigbar oppvekst. I alle ...
    • Loss of interleukin 33 expression in colonic crypts- a potential marker for disease remission in ulcerative colitis 

      Gundersen, Mona Dixon; Goll, Rasmus; Hol, Johanna; Olsen, Trine; Rismo, Renathe; Sørbye, Sveinung Wergeland; Sundnes, Olav; Haraldsen, Guttorm; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)
      Interleukin 33 (IL-33) is a cytokine preferentially elevated in acute ulcerative colitis (UC), inferring a role in its pathogenesis. The role of IL-33 in intestinal inflammation is incompletely understood, with both pro-inflammatory and regulatory properties described. There are also conflicting reports on cellular sources and subcellular location of IL-33 in the colonic mucosa, justifying a closer ...